Genomic-Based Precision Medicine for Neurological and Kidney Disorders
Keywords:
BioGenomic Precision Medicine, Genomic Clinical Integration, Neurodevelopmental Disorders, Kidney Disease Genomics, Precision Therapeutics, Cross-Disciplinary Clinical Management, Multi-Organ Dysfunction, Patient Stratification, Genotype–Phenotype Correlation, Translational Genomics, Biomarker Discovery, Therapeutic Target Identification, Population-Level Precision Medicine, Genomic Counseling, Treatment Modulation Strategies, Secondary Prevention, Integrated Genomic Frameworks, Clinical Decision Support, Systems Precision Medicine.Abstract
BioGenomic Precision Medicine (BP Med), encompassing genomic developments from technology to clinical integration, offers a distinctive perspective on precision medicine in neuro and kidney disorders. In addition to an overview of BP Med, areas of neuro and kidney diseases for which genomic studies have provided insights into therapeutic strategies are considered, as well as cross-disciplinary clinical management of conditions with both neurodevelopmental and kidney features.
Traditionally, precision medicine has focused on targeted therapies for small patient subsets sharing a disorder-associated mutation, epigenetic alteration, or biomarker. BP Med expands this logic from narrow disease targets to include broader and potentially more impactful insights by addressing foundational concepts and resources for the implementation of precision medicine, thereby indirectly enabling stratification of the entire affected population or improving response profiles for all patients, whether by counselling, treatment modulation in multi-organ dysfunctions, or secondary preventive strategies. BP Med invites integration of established but previously compartmentalized genomic knowledge into a more comprehensive and clinically useful frame. Without such inclusion, especially in the neurodevelopmental field, replication may remain elusive, independent comparisons across specialties may lack value, and resolution of plot holes may remain unfulfilled.
